Bepafant
| Code | Size | Price |
|---|
| TAR-T26775-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26775-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26775-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was absent.
CAS:
114776-28-2
Formula:
C23H22ClN5O2S
Molecular Weight:
467.97
Purity:
0.98
SMILES:
Cc1nnc2CN=C(c3c4CC(Cc4sc3-n12)C(=O)N1CCOCC1)c1ccccc1Cl
References
1. Correa-Costa M, Andrade-Oliveira V, Braga TT, Castoldi A, Aguiar CF, Origassa CS, Rodas AC, Hiyane MI, Malheiros DM, Rios FJ, Jancar S, C?mara NO. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Lab Invest. 2014 Apr;94(4):455-66. doi: 10.1038/labinvest.2013.155. PubMed PMID: 24492283.
2. Tsoupras AB, Papakyriakou A, Demopoulos CA, Philippopoulos AI. Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. J Inorg Biochem. 2013 Mar;120:63-73. doi: 10.1016/j.jinorgbio.2012.12.004. PubMed PMID: 23318288.
3. Bae R, Arteaga A, Raj JU, Ibe BO. Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells. Int Arch Allergy Immunol. 2012;158(1):18-26. doi: 10.1159/000330029. PubMed PMID: 22212397.
4. Howard KM, Abdel-Al M, Ditmyer M, Patel N. Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways. Inflamm Res. 2011 Aug;60(8):735-44. doi: 10.1007/s00011-011-0326-5. PubMed PMID: 21432021; PubMed Central PMCID: PMC3134448.