TargetMol

CRA1000

Product Code:
 
TAR-T27080
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
CRA1000, a CRF1 receptor antagonist, involved in the regulation of stress response.
CAS:
226948-11-4
Formula:
C28H33FN4S
Molecular Weight:
476.66
Purity:
0.98
SMILES:
CCN(c1nc(C)cc(n1)N1CCC(=CC1)c1cccc(F)c1)c1ccc(cc1SC)C(C)C

Documents

References

1. Knapp DJ, Overstreet DH, Moy SS, Breese GR. SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. Alcohol. 2004 Feb;32(2):101-11. PubMed PMID: 15163561; PubMed Central PMCID: PMC2871682. 2. Ohata H, Arai K, Shibasaki T. Effect of chronic administration of a CRF(1) receptor antagonist, CRA1000, on locomotor activity and endocrine responses to stress. Eur J Pharmacol. 2002 Dec 20;457(2-3):201-6. PubMed PMID: 12464367. 3. Chaki S, Okuyama S, Nakazato A, Kumagai T, Okubo T, Ikeda Y, Oshida Y, Hamajima Y, Tomisawa K. In vitro pharmacological profile of nonpeptide CRF1 receptor antagonists, CRA1000 and CRA1001. Eur J Pharmacol. 1999 Apr 29;371(2-3):205-11. PubMed PMID: 10357258. 4. Okuyama S, Chaki S, Kawashima N, Suzuki Y, Ogawa S, Nakazato A, Kumagai T, Okubo T, Tomisawa K. Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. J Pharmacol Exp Ther. 1999 May;289(2):926-35. PubMed PMID: 10215672.