TargetMol

Fagaronine chloride

Product Code:
 
TAR-T27301
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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This product comes from: United States.
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Further Information

Bioactivity:
Fagaronine chloride is a potent inhibitor of Topoisomerases I.
CAS:
52259-64-0
Formula:
C21H20ClNO4
Molecular Weight:
385.84
Purity:
0.98
SMILES:
[Cl-].COc1cc2c(ccc3c4cc(OC)c(OC)cc4c[n+](C)c23)cc1O

Documents

References

1. P?rez-Chiesa Y, Narv?ez Z. Evaluation of genotoxicity of the indenoisoquinoline analogues of fagaronine and nitidine in Drosophila melanogaster. Mutat Res. 1993 Apr;301(4):207-12. PubMed PMID: 7680753. 2. Cushman M, Mohan P. Synthesis and antitumor activity of structural analogues of the anticancer benzophenanthridine alkaloid fagaronine chloride. J Med Chem. 1985 Aug;28(8):1031-6. PubMed PMID: 4020826. 3. Janin YL, Croisy A, Riou JF, Bisagni E. Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives. J Med Chem. 1993 Nov 12;36(23):3686-92. PubMed PMID: 8246238. 4. Tan GT, Lee S, Lee IS, Chen J, Leitner P, Besterman JM, Kinghorn AD, Pezzuto JM. Natural-product inhibitors of human DNA ligase I. Biochem J. 1996 Mar 15;314 ( Pt 3):993-1000. PubMed PMID: 8615799; PubMed Central PMCID: PMC1217154.