TargetMol

Incadronate Disodium

Product Code:
 
TAR-T27602
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
Incadronate Disodium is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro.
CAS:
138330-18-4
Formula:
C8H17NNa2O6P2
Molecular Weight:
331.152
Purity:
0.98
SMILES:
[Na+].[Na+].OP([O-])(=O)C(NC1CCCCCC1)P(O)([O-])=O

Documents

References

1. Okamoto T, Yamagishi S, Inagaki Y, Amano S, Takeuchi M, Kikuchi S, Ohno S, Yoshimura A. Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro. Biochem Biophys Res Commun. 2002 Sep 20;297(2):419-24. PubMed PMID: 12237136. 2. Komatsubara S, Mori S, Mashiba T, Ito M, Li J, Kaji Y, Akiyama T, Miyamoto K, Cao Y, Kawanishi J, Norimatsu H. Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. J Bone Miner Res. 2003 Mar;18(3):512-20. PubMed PMID: 12619936. 3. Li C, Mori S, Li J, Kaji Y, Akiyama T, Kawanishi J, Norimatsu H. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001 Mar;16(3):429-36. PubMed PMID: 11277259. 4. Ohno Y, Yamada Y, Usu T, Takahashi K, Tsuchiya F, Ohtani H, Sato H, Sawada Y, Iga T. Pharmacokinetic and pharmacodynamic analysis of the antihypercalcemic effect of incadronate disodium in rats. Biol Pharm Bull. 2001 Nov;24(11):1290-3. PubMed PMID: 11725966.