TargetMol

INCB-9471 HCl

Product Code:
 
TAR-T27604
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27604-5mg5mg£1,332.00
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Quantity:
TAR-T27604-50mg50mg£2,625.00
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Quantity:
TAR-T27604-100mg100mg£3,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
INCB-9471 HCl, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5, has potent inhibitory activity against monocyte migration and HIV-1 infection.
CAS:
869725-27-9
Formula:
C30H42Cl2F3N5O2
Molecular Weight:
632.59
Purity:
0.98
SMILES:
Cl.Cl.CCO[C@@H]1Cc2cc(ccc2[C@H]1N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)C(F)(F)F

References

1. Brown KC, Paul S, Kashuba AD. Drug interactions with new and investigational antiretrovirals. Clin Pharmacokinet. 2009;48(4):211-41. doi: 10.2165/00003088-200948040-00001. Review. PubMed PMID: 19492868; PubMed Central PMCID: PMC2857544. 2. Shin N, Solomon K, Zhou N, Wang KH, Garlapati V, Thomas B, Li Y, Covington M, Baribaud F, Erickson-Viitanen S, Czerniak P, Contel N, Liu P, Burn T, Hollis G, Yeleswaram S, Vaddi K, Xue CB, Metcalf B, Friedman S, Scherle P, Newton R. Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39. doi: 10.1124/jpet.111.179531. PubMed PMID: 21459966.