TargetMol

JG26

Product Code:
 
TAR-T27654
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27654-1mg1mg£152.00
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Quantity:
TAR-T27654-5mg5mg£268.00
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TAR-T27654-10mg10mg£367.00
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TAR-T27654-25mg25mg£570.00
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Quantity:
TAR-T27654-50mg50mg£781.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
JG26 is an ADAM17 inhibitor. JG26 inhibits AngII-induced EGFR transactivation and ERK activation in vascular smooth muscle cells (VSMCs).
CAS:
1464910-32-4
Formula:
C19H22Br2N4O6S
Molecular Weight:
594.28
Pathway:
Immunology/Inflammation|Proteases/Proteasome
Purity:
0.98
SMILES:
NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO
Target:
Immunology/Inflammation related|MMP

References

1. Pharmacological Inhibition of ADAM17 by a Human-Cross Reactive Antibody and Selective Inhibitor JG26 Prevents Vascular Fibrosis Induced by Angiotensin II in vivo and in vitro. Tatsuo Kawai, Steven J Forrester, Kunie Eguchi, Victor Rizzo, Satoru Eguchi, Hang Fai Kwok, Gillian Murphy and Armando Rossello. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36:A557, originally published February 9, 2017