TargetMol

JNJ-10191584

Product Code:
 
TAR-T27658
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
JNJ-10191584, a potent and selective antagonist at the histamine H4 receptor, has antiinflammatory and analgesic effects in animal studies of acute inflammation.
CAS:
73903-17-0
Formula:
C13H15ClN4O
Molecular Weight:
278.74
Purity:
0.98
SMILES:
O=C(C1=NC2=CC(Cl)=CC=C2N1)N3CCN(C)CC3

Documents

References

1. Jochem J, Altinbas B, Yalcin M, Ottani A, Giuliani D, Savci V, Kasperska-Zajac A, Guarini S. Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats. J Physiol Pharmacol. 2016 Feb;67(1):67-74. PubMed PMID: 27010896. 2. Sanna MD, Stark H, Lucarini L, Ghelardini C, Masini E, Galeotti N. Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. Pain. 2015 Dec;156(12):2492-504. doi: 10.1097/j.pain.0000000000000319. PubMed PMID: 26270581. 3. Nos?? R, Jan?inov? V, Dr?bikov? K, Pere?ko T. Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes. Gen Physiol Biophys. 2015 Apr;34(2):209-16. doi: 10.4149/gpb_2014040. Epub 2015 Mar 2. PubMed PMID: 25730898. 4. Kaneko H, Ye F, Ijima R, Kachi S, Kato S, Nagaya M, Higuchi A, Terasaki H. Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration. Br J Pharmacol. 2014 Aug;171(15):3754-63. doi: 10.1111/bph.12737. PubMed PMID: 24787705; PubMed Central PMCID: PMC4128071.