TargetMol

JNJ-17156516

Product Code:
 
TAR-T27664
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
JNJ-17156516 is a potent, and selective cholecystokinin 1 receptor antagonist.
CAS:
649551-06-4
Formula:
C26H22Cl2N2O3
Molecular Weight:
481.37
Purity:
0.98
SMILES:
COc1ccc(cc1)-n1nc(C[C@H](C(O)=O)c2cccc(C)c2)cc1-c1ccc(Cl)c(Cl)c1

Documents

References

1. Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallogr C. 2009 Apr;65(Pt 4):o163-6. doi: 10.1107/S010827010900941X. Epub 2009 Mar 21. PubMed PMID: 19346614; PubMed Central PMCID: PMC2724994. 2. Barrett TD, Yan W, Freedman JM, Lagaud GJ, Breitenbucher JG, Shankley NP. Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction. Br J Pharmacol. 2008 Apr;153(8):1650-8. doi: 10.1038/bjp.2008.44. Epub 2008 Feb 25. PubMed PMID: 18297100; PubMed Central PMCID: PMC2438255. 3. Morton MF, Barrett TD, Yan W, Freedman JM, Lagaud G, Prendergast CE, Moreno V, Pyati J, Figueroa K, Li L, Wu X, Rizzolio M, Breitenbucher JG, McClure K, Shankley NP. 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propio nate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: in vitro and in vivo pharmacological comparison with dexloxiglumide. J Pharmacol Exp Ther. 2007 Nov;323(2):562-9. Epub 2007 Aug 7. PubMed PMID: 17684117.