TargetMol

JNJ-39220675

Product Code:
 
TAR-T27678
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27678-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27678-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27678-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
JNJ-39220675, a selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
CAS:
959740-39-7
Formula:
C21H24FN3O2
Molecular Weight:
369.44
Purity:
0.98
SMILES:
Fc1ccc(Oc2ccc(cn2)C(=O)N2CCCN(CC2)C2CCC2)cc1

References

1. Nuutinen S, Panula P, Salminen O. Different Hypothalamic Nicotinic ?7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats. Alcohol Clin Exp Res. 2016 Feb;40(2):329-34. doi: 10.1111/acer.12960. PubMed PMID: 26842251. 2. Vanhanen J, Kinnunen M, Nuutinen S, Panula P. Histamine H3 receptor antagonist JNJ-39220675 modulates locomotor responses but not place conditioning by dopaminergic drugs. Psychopharmacology (Berl). 2015 Mar;232(6):1143-53. doi: 10.1007/s00213-014-3751-7. Epub 2014 Oct 12. PubMed PMID: 25308376. 3. Barchuk WT, Salapatek AM, Ge T, D'Angelo P, Liu X. A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion. J Allergy Clin Immunol. 2013 Oct;132(4):838-46.e1-6. doi: 10.1016/j.jaci.2013.05.001. Epub 2013 Jun 20. PubMed PMID: 23791513. 4. Vanhanen J, Nuutinen S, Lintunen M, M?ki T, R?m? J, Karlstedt K, Panula P. Histamine is required for H? receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation. Br J Pharmacol. 2013 Sep;170(1):177-87. doi: 10.1111/bph.12170. PubMed PMID: 23489295; PubMed Central PMCID: PMC3764859.