TargetMol

L-749329

Product Code:
 
TAR-T27776
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27776-5mg5mg£1,091.00
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Quantity:
TAR-T27776-50mg50mg£2,143.00
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Quantity:
TAR-T27776-100mg100mg£2,801.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.
CAS:
159590-37-1
Formula:
C28H29NO8S
Molecular Weight:
539.6
Purity:
0.98
SMILES:
CCCc1cc(ccc1OC(C(=O)NS(=O)(=O)c1ccc(cc1)C(C)C)c1ccc2OCOc2c1)C(O)=O

References

1. Maguire JJ, Kuc RE, Davenport AP. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Life Sci. 2012 Oct 15;91(13-14):681-6. doi: 10.1016/j.lfs.2012.05.008. Epub 2012 May 23. PubMed PMID: 22634326. 2. Huckle WR, Drag MD, Acker WR, Powers M, McFall RC, Holder DJ, Walsh TF, Schwartz RS, Greenlee WJ, Johnson RG Jr. Effects of L-749,329, an ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation. 2001 Apr 10;103(14):1899-905. PubMed PMID: 11294810. 3. Hara M, Tozawa F, Itazaki K, Mihara S, Fujimoto M. Endothelin ET(B) receptors show different binding profiles in intact cells and cell membrane preparations. Eur J Pharmacol. 1998 Mar 26;345(3):339-42. PubMed PMID: 9592035. 4. Wu-Wong JR, Chiou WJ, Hoffman DJ, Winn M, von Geldern TW, Opgenorth TJ. Endothelins and endothelin receptor antagonists: binding to plasma proteins. Life Sci. 1996;58(21):1839-47. PubMed PMID: 8637410.