LK 157
Code | Size | Price |
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TAR-T32805-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T32805-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T32805-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.
CAS:
209536-74-3
Formula:
C14H17NO4
Molecular Weight:
263.293
Purity:
0.98
SMILES:
CO[C@H]1CCC[C@@H]2[C@H]3N(C(=O)C3=CC)C(C(O)=O)=C12
References
1. Paukner S, Hesse L, Prezelj A, Solmajer T, Urleb U. In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor. Antimicrob Agents Chemother. 2009 Feb;53(2):505-11. doi: 10.1128/AAC.00085-08. Epub 2008 Dec 15. PubMed PMID: 19075067; PubMed Central PMCID: PMC2630636.
2. Iglicar P, Legen I, Vilfan G, Selic L, Prezelj A. Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro. J Pharm Pharmacol. 2009 Sep;61(9):1211-8. doi: 10.1211/jpp/61.09.0011. PubMed PMID: 19703371.
3. Swathi CH, Chikala R, Ratnakar KS, Sritharan V. A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs). Indian J Med Res. 2016 Jul;144(1):21-31. doi: 10.4103/0971-5916.193279. Review. PubMed PMID: 27834322; PubMed Central PMCID: PMC5116894.
4. Fernea A, Galleni M, Fr?re JM. Kinetics of the Interaction between BAL29880 and LK157 and the Class C ?-Lactamase CHE-1. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1747-50. doi: 10.1128/AAC.02062-15. PubMed PMID: 26729500; PubMed Central PMCID: PMC4775998.