TargetMol

Lolitrem B

Product Code:
 
TAR-T32851
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32851-5mg5mg£850.00
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Further Information

Bioactivity:
Lolitrem B is one of many toxins produced by a fungus called Epichlo? festucae (var. lolii), which grows in perennial ryegrass. The fungus is symbiotic with the ryegrass; it doesn't harm the plant, and the toxins it produces kill insects that feed on ryegrass. Lolitrem B is one of these toxins, but it is also harmful to mammals.
CAS:
81771-19-9
Formula:
C42H55NO7
Molecular Weight:
685.902
Purity:
0.98
SMILES:
CC(C)=C[C@H]1O[C@H]2[C@H]3O[C@@]33[C@H](CCC4(C)[C@]5(C)C(Cc6c5[nH]c5ccc7C(=O)C8C(Cc7c65)C(C)(C)OC8(C)C)CC[C@@]34O)O[C@@H]2C(C)(C)O1

References

1. Repussard C, Zbib N, Tardieu D, Guerre P. Ergovaline and lolitrem B concentrations in perennial ryegrass in field culture in southern France: distribution in the plant and impact of climatic factors. J Agric Food Chem. 2014 Dec 31;62(52):12707-12. doi: 10.1021/jf504581y. Epub 2014 Dec 19. PubMed PMID: 25526521. 2. Johnstone LK, Mayhew IG. Flow-mediated K(+) secretion in horses intoxicated with lolitrem B (perennial ryegrass staggers). N Z Vet J. 2013 May;61(3):159-64. doi: 10.1080/00480169.2012.731682. Epub 2012 Nov 8. PubMed PMID: 23134178. 3. Shimada N, Yoshioka M, Mikami O, Tanimura N, Yamanaka N, Hanazumi M, Kojima F, Miyazaki S. Toxicological evaluation and bioaccumulation potential of lolitrem B, endophyte mycotoxin in Japanese black steers. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(8):1402-6. doi: 10.1080/19440049.2013.790090. Epub 2013 May 31. PubMed PMID: 23721156. 4. Johnstone LK, Mayhew IG, Fletcher LR. Clinical expression of lolitrem B (perennial ryegrass) intoxication in horses. Equine Vet J. 2012 May;44(3):304-9. doi: 10.1111/j.2042-3306.2011.00439.x. Epub 2011 Jul 27. PubMed PMID: 21793878.