TargetMol

MK761

Product Code:
 
TAR-T33437
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
MK761 has β-adrenergic receptor antagonist and vasodilator properties in a single molecule and is as effective at blocking cardiac and vascular β-adrenergic receptors as timolol and indololol. The compound exhibited β-adrenergic receptor blocking activity in vitro in the isolated papillary muscle of the cat heart and in the isolated rat atria.
CAS:
65321-41-7
Formula:
C13H19N3O2
Molecular Weight:
249.314
Purity:
0.98
SMILES:
CC(C)(C)NC[C@H](O)COc1ncccc1C#N

Documents

References

Scriabine A, Ludden CT, Morgan G, Baldwin JJ. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35(12):1634-7. PubMed PMID: 42553. Sweet CS, Scriabine A, Weitz D, Ludden CT, Minsker DH, Stone CA. Antihypertensive and hemodynamic properties of 2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine HCl (MK-761). J Pharmacol Exp Ther. 1979 Oct;211(1):200-6. PubMed PMID: 114619. Mostaghim R, Maddox YT, Ramwell PW. Endothelial potentiation of relaxation response to beta adrenoceptor blocking agents. J Pharmacol Exp Ther. 1986 Dec;239(3):797-801. PubMed PMID: 2879033. Sweet CS, Hall RA, Columbo JM, Wenger HC, Backlund E, Morgan G, Gaul SL, Scriabine A. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211(1):195-9. PubMed PMID: 40012.