TargetMol

Transtinib

Product Code:
 
TAR-T34916
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Transtinib is an effective and irreversible EGFR tyrosine kinase inhibitor (EGFR-TKI) that is active against L858R/T790M mutated NSCLC cell lines and xenografts.
CAS:
1246089-27-9
Formula:
C30H29ClFN5O3
Molecular Weight:
562.04
Purity:
0.98
SMILES:
CCOc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C=C[C@@H]1CCCN1

Documents

References

Hu P, Han D, Ruan R, Zheng LM, Tzeng CM. Transtinib, a potent tyrosine kinase inhibitor inhibits L858R/T790M mutant NSCLC cell lines and xenografts. Oncotarget. 2016 Feb 2. doi: 10.18632/oncotarget.7140. [Epub ahead of print] PubMed PMID: 26848869.