TargetMol

Cryogenine

Product Code:
 
TAR-T38327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38327-5mg5mg£946.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T38327-10mg10mg£1,532.00
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Further Information

Bioactivity:
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.2
CAS:
10308-13-1
Formula:
C26H29NO5
Molecular Weight:
435.5
Purity:
0.98
SMILES:
COC1=CC([C@@]2([H])N3CCCC[C@]3([H])C[C@@]4([H])C2)=C(C5=CC(/C=CC(O4)=O)=CC=C5O)C=C1OC

References

Kosersky, D.S., Brown, J.K., and Malone, M.H. Effects of cryogenine on adjuvant-induced arthritis and serum turbidity in rats. J. Pharm. Sci. 62(12), 1965-1971 (1973). Lema, W.J., Blankenship, J.W., and Malone, M.H. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15(2), 161-167 (1986).