Sugammadex

Product Code:

TAR-T5326L

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T5326L-5mg

5mg

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Further Information

Bioactivity:

Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periphery. This gamma cyclodextrin has been modified from its natural state by placing eight carboxyl thio ether groups at the sixth carbon positions. These extensions extend the cavity size allowing greater encapsulation of the rocuronium molecule. These negatively charged extensions electrostatically bind to the quaternary nitrogen of the target as well as contribute to the aqueous nature of the cyclodextrin.

CAS:

343306-71-8

Formula:

C72H112O48S8

Molecular Weight:

2002.12

Purity:

0.98

SMILES:

O[C@H]1[C@H](O)[C@@H]2O[C@H]3OC(CSCCC(O)=O)[C@@H](O[C@H]4OC(CSCCC(O)=O)[C@@H](O[C@H]5OC(CSCCC(O)=O)[C@@H](O[C@H]6OC(CSCCC(O)=O)[C@@H](O[C@H]7OC(CSCCC(O)=O)[C@@H](O[C@H]8OC(CSCCC(O)=O)[C@@H](O[C@H]9OC(CSCCC(O)=O)[C@@H](OC1OC2CSCCC(O)=O)[C@@H](O)[C@@H]9O)[C@@H](O)[C@@H]8O)[C@@H](O)[C@@H]7O)[C@@H](O)[C@@H]6O)[C@@H](O)[C@@H]5O)[C@@H](O)[C@@H]4O)[C@@H](O)[C@@H]3O

Documents

References

Abad-Gurumeta A, Ripoll?s-Melchor J, Casans-Franc?s R, Espinosa A, Mart?nez-Hurtado E, Fern?ndez-P?rez C, Ram?rez JM, L?pez-Timoneda F, Calvo-Vecino JM; Evidence Anaesthesia Review Group. A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade. Anaesthesia. 2015 Dec;70(12):1441-52. doi: 10.1111/anae.13277. Review. PubMed PMID: 26558858. Ledowski T. Sugammadex: what do we know and what do we still need to know? A review of the recent (2013 to 2014) literature. Anaesth Intensive Care. 2015 Jan;43(1):14-22. Review. PubMed PMID: 25579285. Partownavid P, Romito BT, Ching W, Berry AA, Barkulis CT, Nguyen KP, Jahr JS. Sugammadex: A Comprehensive Review of the Published Human Science, Including Renal Studies. Am J Ther. 2015 Jul-Aug;22(4):298-317. doi: 10.1097/MJT.0000000000000103. Review. PubMed PMID: 25299638. Takazawa T, Mitsuhata H, Mertes PM. Sugammadex and rocuronium-induced anaphylaxis. J Anesth. 2016 Apr;30(2):290-7. doi: 10.1007/s00540-015-2105-x. Epub 2015 Dec 8. Review. PubMed PMID: 26646837; PubMed Central PMCID: PMC4819478.