TargetMol

NSC-87877 disodium

Product Code:
 
TAR-T6911
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6911-5mg5mg£123.00
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Quantity:
TAR-T6911-1mL1 mL * 10 mM (in DMSO)£137.00
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TAR-T6911-10mg10mg£146.00
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TAR-T6911-25mg25mg£227.00
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TAR-T6911-50mg50mg£332.00
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Quantity:
TAR-T6911-100mg100mg£461.00
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Quantity:
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Further Information

Bioactivity:
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
CAS:
56932-43-5
Formula:
C19H11N3Na2O7S2
Molecular Weight:
503.41
Pathway:
Metabolism; Apoptosis
Purity:
0.98
SMILES:
[Na+].[Na+].Oc1c(cc(c2cccnc12)S([O-])(=O)=O)N=Nc1ccc2cc(ccc2c1)S([O-])(=O)=O
Target:
Apoptosis; Phosphatase

Documents

References

Chen L, et al. Mol Pharmacol. 2006, 70(2):562-70. Shi Y, et al. Cell Death Dis. 2015, 6:e1841. Luo Q, et al. Br J Pharmacol. 2014, 171(7):1706-21. Peng HY, et al. Pain. 2012, 153(5):1042-53.