TargetMol

Filanesib

Product Code:
 
TAR-TQ0318
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0318-1mg1mg£98.00
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TAR-TQ0318-5mg5mg£132.00
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TAR-TQ0318-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-TQ0318-10mg10mg£177.00
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TAR-TQ0318-25mg25mg£266.00
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TAR-TQ0318-50mg50mg£389.00
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This product comes from: United States.
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Further Information

Bioactivity:
Filanesib is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.
CAS:
885060-09-3
Formula:
C20H22F2N4O2S
Molecular Weight:
420.48
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9806
SMILES:
CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC
Target:
KSP

References

Tunquist BJ, et al. Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. Mol Cancer Ther. 2010 Jul;9(7):2046-56. Woessner R, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009 Nov;29(11):4373-80. Carter BZ, et al. Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62. Kim KH, et al. KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. J Transl Med. 2009 Jul 20;7:63.