TargetMol

N-Nitroso-N-methyl-4-Aminobutyric Acid

Product Code:
 
TAR-T36415
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3
CAS:
61445-55-4
Formula:
C5H10N2O3
Molecular Weight:
146.146
Purity:
0.98
SMILES:
CN(CCCC(O)=O)N=O

Documents

References

Lijinsky, W., Reuber, M.D., Saavedra, J.E., et al.Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivativesJ. Natl. Cancer Inst.70(5)959-963(1983) Djordjevic, M.V., Brunnemann, K.D., and Hoffmann, D.Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobaccoCarcinogenesis10(9)1725-1731(1989) Janzowski, C., Landsiedel, R., G?lzer, P., et al.Mitochondrial formation of ?-oxopropyl metabolites from bladder carcinogenic ?-carboxyalkylnitrosaminesChem. Biol. Interact.90(1)23-33(1994)