TargetMol

CU-76

Product Code:
 
TAR-T38329
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38329-5mg5mgEnquire
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Further Information

Bioactivity:
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.
CAS:
2400954-58-5
Formula:
C11H8F2IN5O2
Molecular Weight:
407.1
Purity:
0.98
SMILES:
IC1=C(F)C=C(NC2=NC(N)=NC(C(OC)=O)=N2)C=C1F

Documents

References

Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)