TargetMol

BPN-15606

Product Code:
 
TAR-T10589L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T10589L-100mg100mgEnquire
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Further Information

Bioactivity:
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance. BPN-15606 significantly lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice[1].
CAS:
1914989-49-3
Formula:
C23H23FN6O
Molecular Weight:
418.476
Purity:
0.98
SMILES:
COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1

Documents

References

1. Wagner SL, et al. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44.