TargetMol

JI051

Product Code:
 
TAR-T11718
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11718-5mg5mg£370.00
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Quantity:
TAR-T11718-50mg50mg£1,564.00
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Quantity:
TAR-T11718-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
JI051,Anti-cancer activity. is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1.
CAS:
2234281-75-3
Formula:
C22H24N2O3
Molecular Weight:
364.445
Purity:
0.98
SMILES:
CCOc1ccccc1CCNC(=O)C=Cc1c[nH]c2c(OC)cccc12

References

1. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.