TargetMol

JDTic dihydrochloride

Product Code:
 
TAR-T11721L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11721L-100mg100mgEnquire
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TAR-T11721L-50mg50mgEnquire
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  • Further Information
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Further Information

Bioactivity:
JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
CAS:
785835-79-2
Formula:
C28H41Cl2N3O3
Molecular Weight:
538.55
Pathway:
Stem Cells; Chromatin/Epigenetic; JAK/STAT signaling; Angiogenesis
Purity:
0.98
SMILES:
Cl.Cl.CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)NC(=O)[C@H]1Cc2ccc(O)cc2CN1
Target:
JAK

Documents

References

1. Jackson KJ, et al. Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse. Psychopharmacology (Berl). 2010 Jun;210(2):285-94. 2. Schank JR, et al. The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x. 3. Beardsley PM, et al. Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce