TargetMol

K-80003

Product Code:
 
TAR-T11734
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11734-100mg100mgEnquire
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Further Information

Bioactivity:
K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.
CAS:
1292821-90-9
Formula:
C22H21FO2
Molecular Weight:
336.406
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CC(C)c1ccc(C=C2C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
Target:
c-Fms

References

1. Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73. 2. Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR?. Nat Commun. 2017 Jul 17;8:16066.