TargetMol

Phen-DC3 Trifluoromethanesulfonate

Product Code:
 
TAR-T13817L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65?6 and 50?10 nM, respectively).
CAS:
929895-45-4
Formula:
C36H26F6N6O8S2
Molecular Weight:
848.75
Purity:
0.98
SMILES:
[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.C[n+]1cc(NC(=O)c2ccc3ccc4ccc(nc4c3n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12

References

1. Sanjay Kumar Bharti, et al. Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability. J Biol Chem. 2013 Sep 27; 288(39): 28217?28229. 2. Aur?le Piazza, et al. Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J. 2015 Jun 12; 34(12): 1718?1734.