TargetMol

SRPKIN-1

Product Code:
 
TAR-T16931
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T16931-100mg100mgEnquire
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).
CAS:
2089226-94-6
Formula:
C27H21FN2O3S
Molecular Weight:
472.53
Pathway:
Cell Cycle/Checkpoint; Metabolism
Purity:
0.98
SMILES:
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cccc(c1)S(F)(=O)=O
Target:
Serine/threonin kinase

Documents

References

1. Hatcher JM, et al. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 Apr 19;25(4):460-470.e6.