TargetMol

Poloxime

Product Code:
 
TAR-T16559
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
CAS:
17302-61-3
Formula:
C10H13NO2
Molecular Weight:
179.219
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)C1=CC(=N/O)C(C)=CC1=O
Target:
PLK

References

1. Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4. 2. Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.