TargetMol

L-Leucine-1-13C

Product Code:
 
TAR-T32811
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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  • Further Information
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Further Information

Bioactivity:
L-Leucine-1-13C is an essential amino acid that is used in the biosynthesis of proteins. Leucine is an α-amino acid, meaning it contains an α-amino group (which is in the protonated ?NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated ?COO? form under biological conditions), and a side chain isobutyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, and beans and other legumes. In the genetic code, it is encoded by the six codons UUA, UUG, CUU, CUC, CUA, and CUG. Like valine and isoleucine, leucine is a branched-chain amino acid. The primary metabolic end products of leucine metabolism are acetyl-CoA and acetoacetate; consequently, it is one of the two exclusively ketogenic amino acids, with lysine being the other. It is the most important ketogenic amino acid in humans. Leucine and β-hydroxy β-methylbutyric acid, a minor leucine metabolite, exhibit pharmacological activity in humans and have been demonstrated to promote protein biosynthesis via the phosphorylation of the mechanistic target of rapamycin (mTOR).
CAS:
74292-94-7
Formula:
C6H13NO2
Molecular Weight:
132.167
Purity:
0.98
SMILES:
CC(C)C[C@H](N)[13C](O)=O

Documents

References

1. Ye ZW, Peng J, Du Y, An S, Liu Q. Modest leucine supplement for prevention of rheumatic heart disease. Eur J Prev Cardiol. 2018 Jan 1:2047487318780044. doi: 10.1177/2047487318780044. [Epub ahead of print] PubMed PMID: 29808755. 2. Mar?n-S?ez J, Romero-Gonz?lez R, Frenich AG, Egea-Gonz?lez FJ. Screening of drugs and homeopathic products from Atropa Belladonna seed extracts: tropane alkaloids determination and untargeted analysis. Drug Test Anal. 2018 May 28. doi: 10.1002/dta.2416. [Epub ahead of print] PubMed PMID: 29808589. 3. Phupiewkham W, Lu Q, Payoungkiattikun W, Temsiripong T, Jangpromma N, Lai R, Klaynongsruang S. Development and Characterization of an Anti-Acne Gel Containing Siamese Crocodile (Crocodylus siamensis) Leukocyte Extract. J Microbiol Biotechnol. 2018 May 28;28(5):707-717. doi: 10.4014/jmb.1802.02027. PubMed PMID: 29807397. 4. Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018 May 22;47(2):800-816. doi: 10.1159/000490033. [Epub ahead of print] PubMed PMID: 29807365.