Further Information
Alternate Names/Synonyms:
Signal Transducer CD24; Small Cell Lung Carcinoma Cluster 4 Antigen
Recombinant human CD24-muIg blocks binding of recombinant Siglec10 to human Raji cells in FACS.
0.5mg/ml
32160000
liquid
50 mM Sodium Phosphate pH 7.5, 100mM KCl, 150mM NaCl.
Avoid freeze/thaw cycles. Keep sterile.
Preservative Free
Recombinant Protein. The extracellular domain (33aa) of human CD24 is fused to the murine IgG2a Fc (233 aa). Source: W2. 50 mM Sodium Phosphate pH 7.5, 100mM KCl, 150mM NaCl. CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
SDS-PAGE ~90kDa(native) and ~45kDa (reducing conditions)
P25063
Plastic Vial
CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
Protein, Cancer, Immunology, Immuno-Oncology, Inflammation
Protein
The extracellular domain (33aa) of human CD24 is fused to the murine IgG2a Fc (233 aa).
HEK 293 cells
Fc
Non-hazardous
Other Proteins
12352202
Stable for at least 6 months after receipt when stored at +4A°C.
