Leinco Technologies

Recombinant Human IL-5 Rα

Product Code:
 
LEI-I-554
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-554-25ug25 ug£762.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
IL-5 receptor alpha (IL-5 Rα), also known as CD125, is a subunit of the functional heterodimeric IL-5 receptor complex.1 IL-5 is produced primarily by activated T cells and mast cells, and has diverse biological effects on a variety of cell types. It is a potent eosinophil differentiation and activation factor. The IL-5Rα chain is exclusively expressed by eosinophils, some basophils and murine B1 cells or B cell precursors.2 The high affinity receptor complex for IL-5 consist of the ligand binding α chain, IL-5 Rα, and the common beta chain, CD131.3 The α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5 Rα is associated with JAK2, a protein tyrosine-kinase essential in IL-5 signal transduction.4,5 The beta subunit is shared with the high affinity receptor complexes IL-3 and GM-CSF. Like many other cytokine receptors, alternative splicing of the IL-5Rα gene results in expression of either a membrane bound or soluble form. The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. Soluble IL-5 Rα up-regulation has been shown to be involved with the eosinophil-associated disease nasal polyposis.6
NCBI Gene:
3568
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-5 R alpha

References

1. Graham, A. et al. (2000) Cytokine 12:858 2. Coffer, PJ. et al. (2001) Cytokine Growth Factor Rev 12:19 3. Fiers, W. et al. (1991) Cell 66:1175 4. Ishikawa, T. et al. (1998) Blood 91:2264 5. Takatsu, K. et al. (1994) J. Exp. Med. 14:7404 6. Tavernier, J. et al. (2003) Allergy 58:371