Leinco Technologies

Recombinant Human CNTF

Product Code:
 
LEI-C387
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-C387-10ug10 ug£340.00
Quantity:
LEI-C387-50ug50 ug£840.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) and cysteine pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) and cysteine pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Ciliary neurotrophic factor (CNTF), also known as HCNTF, is a cytokine that supports survival and/or differentiation of a variety of neuronal cell types including sensory, sympathetic and motoneurons (1). It is structurally related to IL-6, IL-11, LIF and OSM. CNTF is expressed in glial cells within the central and peripheral nervous systems. It lacks the classical signal peptide sequence of a secreted protein, but is thought to convey its cytoprotective effects after release by some mechanism induced by injury. The receptors for CNTF are CNTF Rα subunit and gp130, which are expressed exclusively in the nervous system and skeletal muscle. In addition to its neuronal actions, CNTF also acts on non-neuronal cells such as glia, hepatocytes, skeletal muscle, embryonic stem cells and bone marrow stromal cells. Because CNTF is predominantly expressed in the nervous system, its modulation may have implications for Parkinson's disease, ALS and cell-replacement therapies for other disorders (2-3). CNTF mimics the biological actions of leptin while overcoming "leptin resistance" and appears to reduce inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle (4). Therefore, it may be a therapeutic target for obesity-related metabolic disease. CNTF is highly conserved across species and exhibits cross-species bioactivity.
NCBI Gene:
1270
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
Ciliary Neurotrophic Factor

References

1. Thoenen, H. et al. (1994) J. Neurobiol. 25:1436 2. Hagg, T. et al. (2008) J. Neurosci. 28:2231 3. Masu, Y. et al. (1993) Nature 365:27 4. Febbraio, MA. et al. (2008) J. Mol. Med. 86:3