Leinco Technologies

Recombinant Human IL-1β

Product Code:
 
LEI-I-183
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-I-183-5ug5 ug£471.00
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LEI-I-183-10ug10 ug£744.00
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LEI-I-183-25ug25 ug£1,302.00
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This product comes from: US.
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Further Information

Format:
This recombinant protein solution was 0.2 um filtered and supplied in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with 5% trehalose and no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein solution was 0.2 um filtered and supplied in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with 5% trehalose and no calcium, magnesium, or preservatives present.
Long Description:
IL-1R1 is an 80 kD transmembrane glycoprotein and a member of the Ig superfamily. IL-1 binds both IL-1R1 and IL-1R2. The ligands IL-1α and IL-1β only commence when binding IL-1R1 because IL-1R2 acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1β, thereby reducing their biological effects. Binding of the ligands to IL-1R1 is enhanced by an accessory protein, IL-1R-AcP. IL-1α can exist as either a 31 kD precursor or an 18 kD mature form. IL-1α is a proinflammatory cell-associated cytokine and IL-1β is a 17.5 kD proinflammatory secreted cytokine. Both IL-1α and IL-1β bind to the same receptor and have similar properties that include stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Furthermore, IL-1β mediates a variety of immune and inflammatory responses. IL-1β is a major cause of severe inflammation in the mouse model of Crohn?s Disease, which makes IL-1β an important target for this disease.
NCBI Gene:
3553
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-1β

References

1. Gelmann, EP. et al. (2008) Cancer Res. 68(17):6896-901. PubMed 2. Arend, WP. et al. (2003) Cytokine Growth Factor Rev. 13:323 3. Nicklin, MJ. et al. (1994) Genomics 19:382 4. Dunn, E. et al. (2001) Trends Immunol. 22:533 5. Samad, TA. et al. (2001) Nature 410:425