Leinco Technologies

Recombinant Human IL-4

Product Code:
 
LEI-I-186
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-I-186-10ug10 ug£420.00
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LEI-I-186-20ug20 ug£534.00
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LEI-I-186-50ug50 ug£1,126.00
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This product comes from: US.
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
NCBI Gene:
3565
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-4

References

1. ?dum, N. et al. (2001) Blood. 97(4):1056-62. Article Link 2. ?dum, N. et al. (2003) J Biol Chem. 278(5):2787-91. Article Link 3. ?dum, N et al. (2001) Leukemia 15:787?793 Article Link 4. Woetmann, A. et al. (2010) Experimental Dermatology 19:1096?1102. Article Link 5. Pike, JW. et al. (2001) PNAS 98:2443 6. Finkelman, FD. et al. (2003) J. Immunol. 170:3835 7. Paludan, SR. et al. (1998) Scand. J. Immunol. 48:459 8. Ryan, JJ. et al. (2007) Crit. Rev. Immunol. 27:15