Leinco Technologies

Recombinant Human MIP-1α

Product Code:
 
LEI-M161
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
 

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CodeSizePrice
LEI-M161-10ug10 ug£477.00
Quantity:
LEI-M161-50ug50 ug£728.00
Quantity:
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This product comes from: US.
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Further Information

Format:
This recombinant protein solutiion is supplied as a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Formulation:
This recombinant protein solutiion is supplied as a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Long Description:
Macrophage inflammatory protein 1 alpha (MIP-1α), also known as CCL3, is a member of the chemokine family (1). Its primary function is as a monocyte chemoattractant, but reports have also demonstrated chemoattractant and adhesive effects by MIP-1α on CD8 T cells, B cells and eosinophils. MIP-1α has been identified as a stem cell inhibitory factor that can block the proliferation of hematopoietic stem cells (2). The functional receptor for MIP-1α is CCR1 and CCR5 and it is has been shown to interact with CCL4 (3). Following acute lung injury in rats, MIP-1α stimulates production of TNF-alpha, which in turn up-regulates vascular adhesion molecules required for neutrophil influx (4). MIP-1α may have a potential role in host defense as a direct antiviral agent. It has been reported to show a significant direct antiviral activity against HSV-1(5).
NCBI Gene:
6348
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
MIP-1 alpha

References

1. Menten, P. et al. (2003) Cytokine Growth Factor Rev. 13:455 2. Cook, DN. et al. (1996) J. Leuko. Biol. 59:61 3. Kaufmann, A. et al. (2001) J. Leuko. Biol. 69:248 4. Ward, PA. et al. (1995) J. Immunol. 154:4793 5. Nakayama, T. et al. (2006) Virology 350:484