Leinco Technologies

Recombinant Human Apolipoprotein E3 (ApoE3)

Product Code:
 
LEI-A218
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-A218-100ug100 ug£369.00
Quantity:
LEI-A218-500ug500 ug£500.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Related Products
  • Show All

Further Information

Format:
This lyophilized protein is 0.2 um sterile filtered and lyophilized from 20 mM Sodium Phosphate, Ph 7.8 + 0.5 mM DTT.
Formulation:
This lyophilized protein is 0.2 um sterile filtered and lyophilized from 20 mM Sodium Phosphate, Ph 7.8 + 0.5 mM DTT.
Long Description:
Apolipoprotein E (ApoE) is a 299 amino acid protein, produced by the liver and circulating macrophages, that is a constituent of every plasma lipoprotein except the smallest low density lipoproteins (LDL). It is a key player in the recycling and redistribution of lipids and cholesterol. ApoE is a ligand with a high affinity for low density lipoprotein receptors (LDLR). It regulates the activity of enzymes that metabolize lipids and also makes lipids soluble. Mice and humans that lack ApoE cannot remove excess lipoproteins from the plasma and have an increased risk of atherosclerosis. Defective binding of ApoE to its receptors will lead to accumulation of cholesterol-rich lipoprotein particles in the plasma; this is the cause of type III hyperlipoproteinemia. There are three main isoforms of ApoE all products of alleles at a single gene locus: E2 (Cys112, Cys158), E3 (C112, Arg158), and E4 (Arg112, Arg158). ApoE3 is the most common isoform and is present in 40-90% of the population.
Purity:
>90% by SDS Page and HPLC
Target:
Apolipoprotein E3

References

1. Sennlaub, F. et al. (2015) J Neurosci. 35(40):13568?76. PubMed 2. Yang, H. et al. (2012) PLoS One. 7(9):e44430. PubMed