Leinco Technologies

Recombinant Human BAFF-R

Product Code:
 
LEI-B131
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Storage:
 
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
 

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LEI-B131-50ug50 ug£580.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
BAFF receptor (BAFF R/TNFRSF13/BlyS) is a type III transmembrane protein and member of the TNF receptor (TNFR) super family. It is highly expressed in spleen, lymph node, resting B cells, peripheral blood leukocytes and to some extent, in activated B cells and resting CD4+ cells. BAFF R plays a role in nearly all stages of differentiation of B cells from development to the maintenance of long-lived bone marrow plasma cells. 1 BAFF R is one of three receptors, including TACI and BCMA, identified for BAFF. BAFF R signals by activation of the NFκB signaling pathway.2 Overexpression of the BAFF R ligand, BAFF, in mice leads to autoimmune characteristics similar to systemic lupus erythematosus (SLE) and Sjogren?s syndrome. Furthermore, high levels of BAFF have been detected in the serum of humans with SLE, rheumatoid arthritis, Sjogren?s syndrome and systemic sclerosis.
NCBI Gene:
115650
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
B-Cell Activating Factor Receptor

References

1. Thompson, JS. et al. (2001) Science 293:2108 2. Mackay, F. et al. (2002) Nature Rev. Immunol. 2:464 3. Moore, PA. et al. (1999) Science 285:260 4. Gross, JA. et al. (2000) Nature 404:995 5. Schneider, P. et al. (1999) J. Exp. Med. 189:1747