Leinco Technologies

Recombinant Human HB-EGF

Product Code:
 
LEI-H1419
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-H1419-50ug50 ug£364.00
Quantity:
LEI-H1419-250ug250 ug£887.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Related Products
  • Show All

Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
Heparin-binding EGF-like growth factor (HB-EGF), also known as DTR and DTS, is a heparin binding, O-glycosylated protein and a member of the EGF family of proteins. It is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. HB-EGF is synthesized as a membrane-anchored precursor that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively. HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparin sulfate proteoglycan. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and certain tumor cells. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function (2). HB-EGF contributes to cell adhesion, invasion, and angiogenesis, which are integral to transcoelomic metastasis in ovarian cancer (3). Production of HB-EGF in vascular smooth muscle cells is induced by angiotensin, thus it may have an important autocrine role in the proliferation of these cells in vascular diseases such as atherosclerosis and hypertension. HB-EGF has been shown to interact with NRD1, zinc finger and BTB domain-containing protein 16 and BAG1.
NCBI Gene:
1839
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
HB-EGF

References

1. Higashiyama, S. et al. (1993) J. Cell Biol. 122:933 2. Higashiyama, S. et al. (2004) Cytokine Growth Factor Rev. 15:13 3. Miyamoto, S. et al. (2008) Mol. Cancer Ther. 7:3441 4. Rubin, JS. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415