Leinco Technologies

Recombinant Human TWEAK R

Product Code:
 
LEI-T244
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
 

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LEI-T244-50ug50 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
TWEAK R (TNFRSF12A/FN14) belongs to the TNF family of transmembrane proteins. The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB. It is expressed in many tissues such as heart, placenta, kidney, pancreas, skeletal muscle and lung and is regulated by a number of different growth factors (1). TWEAK R plays a role in TWEAK-induced endothelial cell migration, proliferation and angiogenesis (2). TWEAK-induced cell death via TWEAK R includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. TWEAK R is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs (3). Recent studies have suggested some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (4).
NCBI Gene:
51330
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
TWEAK R

References

1. Nakayama, M. et al. (2003) J. Immunol. 170:3412. Wiley, SR. et al. (2001) Immunity 15:8373. Feng, SL. et al. (2000) Am. J. Pathol. 156:12534. Desplat-J?go, S. et al. (2005) Clin. Immunol. 117:15