Leinco Technologies

Recombinant Human IL-21

Product Code:
 
LEI-I-452
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-I-452-10ug10 ug£307.00
Quantity:
LEI-I-452-100ug100 ug£915.00
Quantity:
LEI-I-452-500ug500 ug£4,292.00
Quantity:
LEI-I-452-1mg1 mg£6,906.00
Quantity:
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives.
Long Description:
Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.1,2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-153 and is a key factor in the transition between innate and adaptive immune responses.4 The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.5
NCBI Gene:
59067
Purity:
>95% by SDS Page and analyzed by silver stain.
Target:
Interleukin-21

References

1. Foster D et al. (2000) Nature 408: 57 2. Clegg CH et al. (2002) J. Leukoc. Biol. 72: 856 3. Leonard WJ.et al. (2002) Science 298: 1630 4. Joannopoulos K.et al. (2003) J. Immunol. 171: 608 5. Lipsky PE. et al. (2008) Ann Rheum. Dis. 3: 83