Leinco Technologies

Recombinant Mouse RANK Ligand

Product Code:
 
LEI-R1255
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
This recombinant protein solution is stable for up to twelve months when stored at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Upon thawing this protein in the presence of a carrier protein it can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze-thaw cycles..
 

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LEI-R1255-10ug10 ug£630.00
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Further Information

Format:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a member of the tumor necrosis factor family cytokine.1 RANKL is essential for osteoclast formation, activation, and survival.2 RANKL through interaction with its receptor RANK can modulate matrix degradation and inflammation.3 RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy. Consequently, novel drugs specifically targeting RANK, RANKL, and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various ailments associated with bone loss, such as arthritis, periodontal disease, cancer metastases, and osteoporosis.4
NCBI Gene:
21943
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
RANKL

References

1. Takayanagi, H. et al. (2003) Arthritis Res Ther. 5: 20 2. Kostenuik, PJ. et al. (2005) Endocrinology 146: 3235 3. Holven, KB. et al. (2009) Stroke 40: 241 4. Penninger, JM. et al. (2008) Ann N Y Acad Sci. 1143: 123