Leinco Technologies

Recombinant Human M-CSF R

Product Code:
 
LEI-M1237
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-M1237-100ug100 ug£659.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Related Products
  • Show All

Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.1,2,3 It also triggers growth and development of mononuclear phagocytes and placental trophoblasts.4 M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues5 M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.6
NCBI Gene:
1436
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
M-CSF R

References

1. Stanley, ER. et al. (1978) Nature 274: 168 2. Byrne, PV. et al. (1981) J. Cell. Biol. 91: 848 3. Bourette, RP. et al. (2000) Growth Factors 17: 155 4. Stanley, ER. et al. (1996) Bone 18: 355 5. Novak, U. et al. (1996) Oncogene 13: 2607 6. Teitelbaum, SL. et al. (2005) J Clin Invest. 115(12):3418-27.