Leinco Technologies

Recombinant Mouse IL-33 R

Product Code:
 
LEI-I-537
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-537-50ug50 ug£614.00
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Further Information

Antigen Distribution:
ST2 is expressed by subsets of T cells and some innate lymphocytes, eosinophils, basophils, and mast cells.
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
IL-33 is a 30 kD proinflammatory cytokine that belongs to the IL-1 superfamily. It signals inflammation in the body via the stimulation of macrophages, neutrophils, B cells, Th2 cells, eosinophils, basophils and mast cells. IL-33 is a ligand for IL33R (ST2), which is part of a cytokine receptor gene cluster that includes IL-1RI and IL-1RII. IL-33 binds ST2 and complexes with the IL-1R Accessory Protein (IL-1R-AcP) to form a functional signaling receptor complex facilitating the activation of NF-?B and MAP kinase signaling pathways resulting in the production of type 2 cytokines from polarized Th2 cells. IL-33R can exist as a type I transmembrane glycoprotein or a soluble glycoprotein. The soluble IL-33R is thought to serve as a decoy receptor which competitively antagonizes the binding of IL-33 thereby reducing its biological effects. IL-33 has been linked with asthma, allergies, endometriosis, and hay fever. In addition, IL-33 resides in keratinocytes of the skin and is thought to trigger the itching associated with dermatitis when subjected to irritation or allergic conditions. Furthermore, in APP/PS1 mice, IL-33 has been shown to be effective in reversing the buildup and preventing the new formation of amyloid plaques that are characteristic of Alzheimer?s disease. However, the action of extracellular IL-33 is limited due to rapid oxidation that causes a molecular conformational change which prevents it from binding to the ST2 receptor.
NCBI Gene:
77125
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
IL-33 R

References

1. Barksby, HE. et al. (2007) Clin. Exp. Immunol. 149:2172. Schmitz, J. et al. (2005) Immunity 23:4793. Lecart, S. et al. (2002) Eur. J. Immunol. 32:29794. Brint, EK. et al. (2004) Nat. Immunol. 5:3735. Weinberg, EO. et al. (2002) Circulation 106:29616. Xu, D. et al. (1998) J. Exp. Med. 187:7877. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:69308. Kato, A. et al. (2007) Curr. Opin. Immunol. 19:7119. Allakhverdi, Z. et al. (2007) J. Immunol. 179:205110. Palmer, G. et al. (2008) Cytokine 42:358