Leinco Technologies

Recombinant Human CXCL16 (Extracellular Domain)

Product Code:
 
LEI-C1335
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-C1335-25ug25 ug£432.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
CXC chemokine ligand 16 (CXCL16), also known as SR-PSOX, is a 20 kDa type I transmembrane protein. It acts as a scavenger receptor on macrophages, which specifically binds to oxidized low density lipoprotein, suggesting that it may be involved in pathophysiology such as atherogenesis. (1) CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo. It is found in liver tissue and influences the uptake, subcellular localization and cytokine profile induced by D oligonucleotides (2-3). It is produced by dendritic cells found in the T cell zones of lymphoid organs and by cells found in the red pulp of the spleen (4). Cells that bind and migrate in response to CXCL16 include several subsets of T cells and natural killer T (NKT) cells (4). Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. It may play a pro-inflammatory role in Inflammatory Bowel Disease (IBD), particularly Crohn's disease (5).
NCBI Gene:
58191
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
CXCL16

References

1. Mummidi, S. et al. (2004) J. Biol. Chem. 279:3188 2. Adams, DH. et al. (2005) J. Immunol. 174:1055 3. Clinman, DM. et al. (2006) J. Immunol. 177:1575 4. Matloubian, M. et al. (2000) Nat. Immunol. 1:298 5. Broedl, UC. et al. (2008) Scand. J. Gastroenterol. 43:283