Leinco Technologies

Recombinant Mouse IL-18 BPd

Product Code:
 
LEI-I-547
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-547-100ug100 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Long Description:
IL-18-binding protein (IL-18BP) is a secreted glycoprotein in the IL-1 family of ligands, however, it bears no amino acid sequence homology to the membrane-associated IL-18 and IL-1 receptor proteins. IL-18BP functions as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL-18 levels during inflammation (1). It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma, which suggests IL-18 activity is modulated by a negative feedback mechanism via IL-18BP. There are four known variants of IL-18BP (a, b, c & d). The isoform IL-18BPd, also known as MC54L, lacks a complete Ig domain and the ability to bind or neutralize IL-18 (2). IL-18BPd has been shown to be produced as a secreted full-length molecule that binds cell surface glycosaminoglycans in the extracellular matrix and also as a furin-cleaved form that contains only the IL-18 binding domain (3). It is related to a secreted viral protein, vIL-18BP, and may contribute to the lack of inflammatory responses characteristic of molluscum contagiosum virus lesions (4).
NCBI Gene:
16068
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
IL-18BPd

References

1. Novick, D. et al. (1999) Immunity 10:127 2. Kim, SH. et al. (2000) Proc. Nat. Acad. Sci. (USA) 197:1190 3. Xiang, Y. et al. (2003) J. Virol. 77:2623 4. Xiang, Y. et al. (1999) Proc. Nat. Acad. Sci. (USA) 96:11537