Leinco Technologies

Recombinant Human FGF-21

Product Code:
 
LEI-F1021
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
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LEI-F1021-25ug25 ug£455.00
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Further Information

Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in MES, sodium sulphate (Na2SO4), ethylenediaminetetraacetic acid (EDTA), and dithiothreitol (DTT).
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in MES, sodium sulphate (Na2SO4), ethylenediaminetetraacetic acid (EDTA), and dithiothreitol (DTT).
Long Description:
Fibroblast growth factor 21 (FGF-21), is a secreted member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion (1). FGF-21 mRNA is most abundant in the liver. It is induced by a nuclear receptor heterodimer that includes RXR and utilizes Klotho family members for signal transduction. FGF-21 signals through the FGFR1c and FGFR4 receptors and stimulates insulin independent glucose uptake by adipocytes (2). It shows poor binding to the ECM and limited binding to heparin. FGF-21 decreases the expression of IGF-1, induces hepatic expression of IGFBP1 and blunts growth hormone signaling (3). Thus, FGF-21 may play a central role in inhibiting growth as part of its broader role in inducing the adaptive response to starvation. FGF21 has the potential to become a powerful therapeutic to treat hepatic steatosis, obesity and type 2 diabetes (4).
NCBI Gene:
26291
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
FGF-21

References

1. Itoh, N. et al. (2000) Biochim. Biophys. 1492:203 2. Shanafelt, AB. et al. (2005) J. Clin. Invest. 115:162 3. Inagaki, T. et al. (2008) Cell Metab. 8:77 4. V?niant, MM. et al. (2009) Diabetes 58:250