Leinco Technologies

Recombinant Human TNF RI

Product Code:
 
LEI-T390
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-T390-50ug50 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Tumor necrosis factor receptor superfamily, member 1A, (TNFRI) also known as TNFRSF1A or CD120A is the principal receptor through which many of the pro-inflammatory activities of TNFα are mediated.2 TNFRI contains a death domain through which it interacts with other death-domain proteins to promote cellular responses.2 TNFRI is found in both membrane-bound and soluble forms. It interacts with membrane-bound or soluble forms of its ligand (TNFα), respectively. Binding of membrane-bound TNFα to the membrane-bound receptor is involved in cell survival, apoptosis, and inflammation by inducing receptor trimerization and activation. 4 Proteolytic processing of TNFRI yields the release of the soluble form of the receptor (TNFsRI), which inhibits inflammation via the interaction with free TNFα.
NCBI Gene:
7132
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
sTNF RI

References

1. Matthews, N. and Neale, ML. (1987). Lymphokines and Interferons, A Practical Approach 221-225. 2. Dana, R. et al. (2000) Arch Ophthalmol. 118: 1666 3. Donner, DB. et al. (2008) J Immunol. 181: 1288 4. Pasparakis, M. et al. (2008) Nat Immunol. 9: 1015