Leinco Technologies

Recombinant Human Amphiregulin

Product Code:
 
LEI-A338
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-A338-100ug100 ug£580.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Amphiregulin (AR), also known as AREGB, is a glycosylated, heparin binding protein and member of the EGF family of cytokines (1). AR is an autocrine growth factor as well as a mitogen, for astrocytes, Schwann cells and fibroblasts. The soluble form of AR is released by proteolytic cleavage. AR binds to the same receptors as EGF and TGF-α, albeit with lower affinity, and can functionally replace EGF and TGF-α in murine keratinocytes (2). Its expression can be induced by phorbol ester, estrogen, androgen and other EGFR ligands (3). In vitro, AR inhibits the growth of various human carcinoma cell lines; contrastingly, the proliferation of some tumor cell, fibroblasts and normal cells is enhanced by AR (4-6). Overexpression of AR is reported in human cancers of breast, colon, stomach and pancreas, as well as in psoriatic epidermis.
NCBI Gene:
374
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
Amphiregulin

References

1. Shoyab, M. et al. (1989) Science 243:1074 2. Johnson, GR. et al. (1993) J. Biol. Chem. 268:2924 3. Thompson, S. et al. (1996) J. Biol. Chem. 271:17927 4. Johnson, GR. et al. (1992) J. Cell Biol. 118:741 5. Salomon, DS. et al. (1995) Breast Cancer Res. Treat. 33:103 6. Cook, PW. et al. (1992) Cancer Res. 52:3324