Leinco Technologies

Recombinant Human FGFR4

Product Code:
 
LEI-F1047
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-F1047-50ug50 ug£659.00
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This product comes from: US.
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity1 that is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous.2 FGFR4 plays essential roles in systemic lipid and glucose homeostasis.3 FGFR4 may be an important regulator of osteogenesis with involvement in preosteoblast proliferation and differentiation as well as osteoblast functioning during intramembranous ossification.4 FGFR-4 signaling and receptor turnover are important potential therapeutic targets in prostate cancer.2
NCBI Gene:
2264
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
FGF R4

References

1. Habuchi, T. et al. (2008) Int J Cancer 123: 2574 2. Ittmann, MM. et al. (2008) Neoplasia 10: 847 3. McKeehan, WL. et al. (2007) Diabetes 56: 2501 4. Nurcombe, V. et al. (2002) Int J Dev Biol. 46: 519