Leinco Technologies

Recombinant Human ACE-2 (His-tag)

Product Code:
 
LEI-A352
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Polar Packs
Storage:
 
Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at -20° to -70°C for three months without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
 

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CodeSizePrice
LEI-A352-10ug10 ug£614.00
Quantity:
LEI-A352-100ug100 ug£2,207.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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  • Further Information
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Further Information

Format:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), zinc chloride (ZnCl2), tris and glycerol.
Formulation:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), zinc chloride (ZnCl2), tris and glycerol.
Long Description:
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].1 ,or the conversion of angiotensin II to angiotensin 1-7.2 ACE 2 has direct effects on cardiac function2, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.3 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).4 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).5
NCBI Gene:
59272
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
ACE-2

References

1. Acton, S. et al. (2000) Circ Res. 87: E1 2. Gamliel-Lazarovich, A. et al. (2007) Cardiovasc Res. 73: 463 3. Nabel, EG. et al. (2000) N Engl J Med. 347: 1795 4. Raizada, MK. et al. (2009) Am J Respir Crit Care Med. 179(11):1048-54. 5. Yuan, Y. et al. (2009) Tohoku J Exp Med. 217: 123