Leinco Technologies

Recombinant Human TrkA

Product Code:
 
LEI-T382
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-T382-50ug50 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC and TrkE, which are members of the neurotropic tyrosine kinase receptor family. They are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates to activate multiple downstream effector proteins (1-2). Phosphorylation of TrkA is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth (3). Also, phosphorylation is required for PI3-kinase association and activation of the Akt signaling cascade. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Expression of Trk receptors also plays an important role in the biology and clinical behavior of neuroblastomas. High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas (4).
NCBI Gene:
4914
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
TrkA

References

1. Esposito, D. et al. (2001) J. Biol. Chem. 276:32687 2. Sofroniew, MV. et al. (2001) Annu. Rev. Neurosci. 24:1217 3. Gu, H. et al. (2000) Mol. Cell. Biol. 20:7109 4. Eggert, A. et al. (2005) Cancer Lett. 228:143